The new Virtual Issue (Vol. 26, 2026) of the journal Protein Science focuses on “Integration of mitochondria into the cellular proteostasis network”, corresponding to our priority program SPP2453. In this special issue of Protein Science, the current understanding of mitochondrial protein biogenesis regarding protein targeting, protein import pathways, assembly processes and quality control mechanisms is covered by experts in the field. Recent research tremendously increased our understanding of these processes and highlighted the role of cellular proteostasis factors.
The emerging topics of protein targeting and quality control mechanisms are central issues of our scientific research consortium, the priority program SPP2453 funded by the German Research Foundation (DFG) since 2024. Our consortium brings together experts in the fields of mitochondria and protein quality control to study how mitochondrial protein biogenesis is integrated into the cellular proteostasis network.
See all articles here:
Heller EM, Lenhard S, Rapaport D, Herrmann J (2026) Mitochondrial presequences are more than just address labels. Protein Sci. 35(3):e70491.
van der Schans F, Tokatlidis K, Vitali DG (2026) In and out of the mitochondrial intermembrane space. Protein Sci. 35(3):e70493.
Hees JT, Harbauer AB (2026) The endoplasmic reticulum in mitochondrial protein targeting: A neuronal perspective on organelle crosstalk. Protein Sci. 35(3):e70506.
Tiku V, Bossenz G, Kirstein J, Becker T (2026) Functions of J-domain proteins in mitochondrial protein biogenesis. Protein Sci. 35(4):e70516.
Palmer CS, Leeming PJ, Stojanovski D (2026) From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family. Protein Sci. 35(4):e70537.
Carlström A, Vazquez-Calvo C, Ott M (2026) The complexities of respiratory chain biogenesis and maintenance in yeast mitochondria. Protein Sci. 35(4):e70545.
Kroczek L, Langer T (2026) Proteolytic control of mitochondrial protein translocases. Protein Sci. 35(5):e70553.
Matsumoto S, Ono S, Endo T (2026) Proteostasis at the mitochondrial outer membrane: Quality control of mitochondrial protein transport. Protein Sci. 35(5):e70587.
Goldstein M, Lee-Glover L, Weidberg H (2026) Quality control of protein import into mammalian mitochondria. Protein Sci. 35(5):e70585.
Schneider J, Guillerm U, Pereira CS, Schanda P (2026) Dynamic disorder is crucial for mitochondrial protein import. Protein Sci. 35(6):e70630.
Ritzenhofen K, Rossi S, Mogk A, den Brave F (2026) The role of the nucleus in the control of mitochondrial precursor proteins in yeast. Protein Sci. 35(6):e70622.
Shankar S, Meisinger C (2026) Orchestrating mitochondrial protein import: The emerging role of DYRK1A in health and disease. Protein Sci. 35(6):e70631.
Horten P, Song K, Pfanner N, Rampelt H (2026) MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function. Protein Sci. 35(6):e70653.
Hasberg L, Lauterbach VK, Ochsenreiter T, Riemer J (2026) Redox signals and oxidative stress in the control of mitochondrial protein import. Protein Sci. 35(7):e70665.
Bertgen L, Chacinska A (2026) Regulation of mitochondrial protein translocases. Protein Sci. 35(7):e70662.
Sharma L, Chakroborty S, Das H, Oeljeklaus S, Bender J, Warscheid B (2026) Mass spectrometry proteomics for studying mitostasis. Protein Sci. 35(7):e70673.
Kvasov NA, Bykov YS (2026) Co-translational protein targeting to mitochondria in the context of co-translational protein maturation. Protein Sci. 35(7):e70682.
Reichert LJ, Vögtle FN, Peselj C (2026) Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality. Protein Sci. 35(8):e70703.
Dennerlein S, Rehling P (2026) Adaptation of OXPHOS biogenesis to cellular requirements. Protein Sci. 35(9):e70763.